HMB-45 expression is found in the cytoplasm of the melanoma cells by anti-HMB-45.
HMB-45 (HMB-45) Mouse Monoclonal Antibody
Specialties: Dermatopathology
Updated: 2022-09-15 12:46:21
Anti-HMB45 is a useful melanoma immunohistochemical marker that reacts with antigens present on immature melanosomes. Anti-HMB45 is useful for identifying amelanotic melanoma from other neoplastic lesions with similar morphology.1-5
- Gown AM, et al. Monoclonal antibodies specific for melanocytic tumors distinguish subpopulations of melanocytes. Am J Pathol. 1986; 123:195-203.
- Wick MR, et al. Immunohistochemical diagnosis of sinonasal melanoma, carcinoma, and neuroblastoma with monoclonal antibodies HMB-45 and anti-synaptophysin. Arch Pathol Lab Med. 1988; 112:616-20.
- Abrahamsen HN, et al. Sentinel lymph nodes in malignant melanoma: extended histopathologic evaluation improves diagnostic precision. Cancer. 2004; 100:1683-91.
- Vaggelli L, et al. Radioisotopic lymphatic mapping of the sentinel node in melanoma: importance of immunohistochemistry. Tumori. 2000; 86:346-8.
- Baisden BL, et al. HMB-45 immunohistochemical staining of sentinel lymph nodes: a specific method for enhancing detection of micrometastases in patients with melanoma. Am J Surg Pathol. 2000; 24:1140-6.
Specifications
- Reactivity: paraffin
- Control: Melanoma (Cytoplasmic)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 7.0 (CMC28229070)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 282M-94 |
| 0.5 mL concentrate | 282M-95 |
| 1.0 mL concentrate | 282M-96 |
| 1.0 mL predilute ready-to-use | 282M-97 |
| 7.0 mL predilute ready-to-use | 282M-98 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 282M-94 |
| 0.5 mL concentrate | 282M-95 |
| 1.0 mL concentrate | 282M-96 |
| 1.0 mL predilute ready-to-use | 282M-97 |
| 7.0 mL predilute ready-to-use | 282M-98 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 282M-94 |
| 0.5 mL concentrate | 282M-95 |
| 1.0 mL concentrate | 282M-96 |
| 1.0 mL predilute ready-to-use | 282M-97 |
| 7.0 mL predilute ready-to-use | 282M-98 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 282M-94-RUO |
| 0.5 mL concentrate (RUO) | 282M-95-RUO |
| 1.0 mL concentrate (RUO) | 282M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 282M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 282M-98-RUO |
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