TdT Rabbit Polyclonal Antibody
Specialties: Hematopathology
TdT (terminal deoxynucleotidyl transferase) is a template-independent DNA polymerase that adds nucleotides randomly to single-stranded DNA. This randomization plays a role in acquired immunity by increasing antigen receptor diversity and aiding in the generation of immunoglobulins and T-cell antigen receptors.1 TdT immunoreactivity is observed mainly in thymus.2 Anti-TdT is often used to visualize lymphoblastic lymphomas,3 and has also been observed in some cases of acute myeloid leukemia.4
- Motea, Edward A, and Anthony J Berdis. "Terminal deoxynucleotidyl transferase: the story of a misguided DNA polymerase." Biochimica et biophysica acta vol. 1804,5 (2010): 1151-66.
- Strauchen, James A, and Lorraine K Miller. "Lymphoid progenitor cells in human tonsils." International journal of surgical pathology vol. 11,1 (2003): 21-4.
- Suzumiya, J et al. "Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections: a useful method for the diagnosis of lymphoblastic lymphoma." The Journal of pathology vol. 182,1 (1997): 86-91.
- Arber, D A, and K A Jenkins. "Paraffin section immunophenotyping of acute leukemias in bone marrow specimens." American journal of clinical pathology vol. 106,4 (1996): 462-8.
Specifications
- Reactivity: paraffin
- Control: Thymus (Nuclear)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 6.0 (CMC33817060)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 338A-74 |
| 0.5 mL concentrate | 338A-75 |
| 1.0 mL concentrate | 338A-76 |
| 1.0 mL predilute ready-to-use | 338A-77 |
| 7.0 mL predilute ready-to-use | 338A-78 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 338A-74 |
| 0.5 mL concentrate | 338A-75 |
| 1.0 mL concentrate | 338A-76 |
| 1.0 mL predilute ready-to-use | 338A-77 |
| 7.0 mL predilute ready-to-use | 338A-78 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 338A-74 |
| 0.5 mL concentrate | 338A-75 |
| 1.0 mL concentrate | 338A-76 |
| 1.0 mL predilute ready-to-use | 338A-77 |
| 7.0 mL predilute ready-to-use | 338A-78 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 338A-74-RUO |
| 0.5 mL concentrate (RUO) | 338A-75-RUO |
| 1.0 mL concentrate (RUO) | 338A-76-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 338A-77-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 338A-78-RUO |
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