TTF-1 (8G7G3/1) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology Pulmonary Pathology
Thyroid transcription factor-1 (TTF-1) is a transcription factor that plays a role in regulating genes expressed within the thyroid, lung, and brain. TTF-1 expression is present in normal thyroid epithelium and type II pneumocytes and nonciliated bronchiolar secretory cells of the lung. TTF-1 expression is seen in most primary lung and thyroid carcinomas, but rarely in other carcinomas. Anti-TTF-1 immunohistochemistry is useful for identifying carcinomas of thyroid and lung origin. 1-9
- Bejarano, P A et al. "Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 9,4 (1996): 445-52.
- Holzinger, A et al. "Monoclonal antibody to thyroid transcription factor-1: production, characterization, and usefulness in tumor diagnosis." Hybridoma vol. 15,1 (1996): 49-53.
- Saad, Reda S et al. "Utility of immunohistochemistry in separating thymic neoplasms from germ cell tumors and metastatic lung cancer involving the anterior mediastinum." Applied immunohistochemistry & molecular morphology : AIMM vol. 11,2 (2003): 107-12.
- Di Loreto, C et al. "Immunocytochemical expression of tissue specific transcription factor-1 in lung carcinoma." Journal of clinical pathology vol. 50,1 (1997): 30-2.
- Abutaily, A S et al. "Immunohistochemistry in the distinction between malignant mesothelioma and pulmonary adenocarcinoma: a critical evaluation of new antibodies." Journal of clinical pathology vol. 55,9 (2002): 662-8.
- Di Loreto, C et al. "Immunocytochemical expression of tissue specific transcription factor-1 in lung carcinoma." Journal of clinical pathology vol. 50,1 (1997): 30-2.
- Katoh, R et al. "Thyroid transcription factor-1 in normal, hyperplastic, and neoplastic follicular thyroid cells examined by immunohistochemistry and nonradioactive in situ hybridization." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 13,5 (2000): 570-6.
- Jang, K Y et al. "Utility of thyroid transcription factor-1 and cytokeratin 7 and 20 immunostaining in the identification of origin in malignant effusions." Analytical and quantitative cytology and histology vol. 23,6 (2001): 400-4.
- Srodon, M, and W H Westra. "Immunohistochemical staining for thyroid transcription factor-1: a helpful aid in discerning primary site of tumor origin in patients with brain metastases." Human pathology vol. 33,6 (2002): 642-5.
Specifications
- Reactivity: paraffin
- Control: Lung Adenocarcinoma (Nuclear)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC34329050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 343M-90 |
| 0.1 mL concentrate | 343M-94 |
| 0.5 mL concentrate | 343M-95 |
| 1.0 mL concentrate | 343M-96 |
| 1.0 mL predilute ready-to-use | 343M-97 |
| 7.0 mL predilute ready-to-use | 343M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 343M-90 |
| 0.1 mL concentrate | 343M-94 |
| 0.5 mL concentrate | 343M-95 |
| 1.0 mL concentrate | 343M-96 |
| 1.0 mL predilute ready-to-use | 343M-97 |
| 7.0 mL predilute ready-to-use | 343M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 343M-90 |
| 0.1 mL concentrate | 343M-94 |
| 0.5 mL concentrate | 343M-95 |
| 1.0 mL concentrate | 343M-96 |
| 1.0 mL predilute ready-to-use | 343M-97 |
| 7.0 mL predilute ready-to-use | 343M-98 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 343M-90-RUO |
| 0.1 mL concentrate (RUO) | 343M-94-RUO |
| 0.5 mL concentrate (RUO) | 343M-95-RUO |
| 1.0 mL concentrate (RUO) | 343M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 343M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 343M-98-RUO |
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