Glypican-3 antibody displays a diffuse and cytoplasmic staining pattern in the neoplastic cells of hepatocellular carcinoma. Note non-neoplastic hepatocytes are negative for glypican-3.
Glypican-3 (1G12) Mouse Monoclonal Antibody
Specialties: Gastrointestinal (GI) Pathology
Updated: 2022-07-05 10:57:03
Glypican-3 (GPC3) is a membrane-bound heparin sulfate proteoglycan known to participate in cell growth and differentiation.1 GPC3 expression has been observed in the majority of hepatocellular carcinomas (HCC), but is rarely expressed in non-neoplastic hepatic tissue, making it a useful marker for HCC.1-3 Additionally, this marker is expressed in many yolk sac tumors.1,4
- Kandil DH, et al. Glypican-3 a novel diagnostic marker for hepatocellular carcinoma and more. Adv Anat Pathol. 2009; 16:125-9.
- Coston WMP, et al. Distinction of hepatocellular carcinoma from benign hepatic mimickers using Glypican-3 and CD34 immunohistochemistry. Am J Surg Pathol. 2008; 32:433-44.
- Capurro M, et al. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology. 2003; 125:89-97.
- Zynger DL, et al. Glypican 3: a novel marker in testicular germ cell tumors. Am J Surg Pathol. 2006; 30:1570-5.
Specifications
- Reactivity: paraffin
- Control: Hepatocellular carcinoma (Cytoplasmic)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 7.0 (CMC26129070)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 261M-90 |
| 0.1 mL concentrate | 261M-94 |
| 0.5 mL concentrate | 261M-95 |
| 1.0 mL concentrate | 261M-96 |
| 1.0 mL predilute ready-to-use | 261M-97 |
| 7.0 mL predilute ready-to-use | 261M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 261M-90 |
| 0.1 mL concentrate | 261M-94 |
| 0.5 mL concentrate | 261M-95 |
| 1.0 mL concentrate | 261M-96 |
| 1.0 mL predilute ready-to-use | 261M-97 |
| 7.0 mL predilute ready-to-use | 261M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 261M-90 |
| 0.1 mL concentrate | 261M-94 |
| 0.5 mL concentrate | 261M-95 |
| 1.0 mL concentrate | 261M-96 |
| 1.0 mL predilute ready-to-use | 261M-97 |
| 7.0 mL predilute ready-to-use | 261M-98 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 261M-90-RUO |
| 0.1 mL concentrate (RUO) | 261M-94-RUO |
| 0.5 mL concentrate (RUO) | 261M-95-RUO |
| 1.0 mL concentrate (RUO) | 261M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 261M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 261M-98-RUO |
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