Uroplakin III (AU-1) Mouse Monoclonal Antibody
Specialties: Genitourinary (GU) Pathology
Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. In non-neoplastic mammalian urothelium, UPs are expressed in the luminal surface plasmalemma of superficial (umbrella) cells, forming complexes of 16nm crystalline particles. UPIII is specific for tumors of urothelial origin and, when used in combination with other markers, can aid in the diagnosis of primary and metastatic tumors.1-4
- Moll R, et al. Uroplakins, specific membrane proteins of urothelial umbrella cells, as histological markers of metastatic transitional cell carcinomas. Am J Pathol. 1995; 147:1383-97.
- Olsburgh J, et al. Uroplakin gene expression in normal human tissues and locally advanced bladder cancer. J Pathol. 2003; 199:41-9.
- Parker DC, et al. Potential utility of uroplakin III, thrombomodulin, high molecular weight cytokerain and cytokeratin 20 in noninvasive, invasive, and metastatic urothelial (transitional cell) carcinomas. Am J Surg Pathol. 2003; 27:1-10.
- Ohtsuka Y, et al. Loss of uroplakin III expression is associated with a poor prognosis in patients with urothelial carcinoma of the upper urinary tract. BJU Int. 2006; 97:1322-6.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic, membranous
- Control: bladder
- Dilution Range: 1:25-1:100*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC34521040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 345M-14 |
| 0.5 mL concentrate | 345M-15 |
| 1 mL concentrate | 345M-16 |
| 1 mL predilute | 345M-17 |
| 7 mL predilute | 345M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 345M-14 |
| 0.5 mL concentrate | 345M-15 |
| 1 mL concentrate | 345M-16 |
| 1 mL predilute | 345M-17 |
| 7 mL predilute | 345M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 345M-14 |
| 0.5 mL concentrate | 345M-15 |
| 1 mL concentrate | 345M-16 |
| 1 mL predilute | 345M-17 |
| 7 mL predilute | 345M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 345M-14-RUO |
| 0.5 mL concentrate | 345M-15-RUO |
| 1 mL concentrate | 345M-16-RUO |
| 1 mL predilute | 345M-17-RUO |
| 7 mL predilute | 345M-18-RUO |
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