C4d Rabbit Polyclonal Antibody
Specialties: Anatomic Pathology
Acute humoral rejection is mediated by antibodies to the donor endothelium that activate the classical complement pathway.1-3 This leads to a number of split products of complement proteins. C4d is a fragment of C 4 complement released during activation of the classic complement pathway by the antigen antibody complex.3 C4d deposits in peritubular capillaries and is regarded as an indirect sign of an antibody response.3,6 C4d can be a useful tool for indicating acute renal allograft rejection.1-6
- Jianghua C, et al. C4d as a significant predictor for humoral rejection in renal allografts. Clin Transplant. 2005; 19:785-91.
- Kayler LK, et al. Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d. Transplantation. 2008; 85:813-20.
- Ranjan P, et al. The role of C4d immunostaining in the evaluation of the causes of renal allograft dysfunction. Nephrol Dial Transplant .2008; 23:1735-41.
- Nadasdy GM, et al. Comparative study for the detection of peritubular capillary C4d deposition in human renal allografts using different methodologies. Hum Pathol. 2005; 36:1178-85.
- Seemayer CA, et al. C4d staining of renal allograft biopsies: a comparative analysis of different staining techniques. Nephrol Dial Transplant. 2007; 22:568-76.
- Bouron-Dal Soglio D, et al. An immunohistochemical evaluation of C4d deposition in pediatric inflammatory liver diseases. Hum Pathol. 2008; 39:1103-10.
Specifications
- Reactivity: paraffin
- Control: Lymph Node (Cytoplasmic, Membranous); Tonsil (Cytoplasmic, Membranous); Acute rejected kidney transplant (Cytoplasmic, Membranous)
- Dilution Range: 1:50-1:200 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC40411050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 404A-14 |
| 0.5 mL concentrate | 404A-15 |
| 1.0 mL concentrate | 404A-16 |
| 1.0 mL predilute ready-to-use | 404A-17 |
| 7.0 mL predilute ready-to-use | 404A-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 404A-14 |
| 0.5 mL concentrate | 404A-15 |
| 1.0 mL concentrate | 404A-16 |
| 1.0 mL predilute ready-to-use | 404A-17 |
| 7.0 mL predilute ready-to-use | 404A-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 404A-14 |
| 0.5 mL concentrate | 404A-15 |
| 1.0 mL concentrate | 404A-16 |
| 1.0 mL predilute ready-to-use | 404A-17 |
| 7.0 mL predilute ready-to-use | 404A-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 404A-14-RUO |
| 0.5 mL concentrate (RUO) | 404A-15-RUO |
| 1.0 mL concentrate (RUO) | 404A-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 404A-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 404A-18-RUO |
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