CD1a (EP3622) Rabbit Monoclonal Primary Antibody
Specialties: Hematopathology
CD1a is a non-polymorphic, major histocompatibility complex, class I-related cell surface glycoprotein (45 to 55 kDa) and is expressed in association with β-microglobulin.1 In normal tissues, anti-CD1a reacts with cortical thymocytes, Langerhans cells, interdigitating cells, and rare antigen-presenting cells of the lymph node.2 CD1a positivity has also been seen in Langerhans cell histiocytosis (histiocytosis X)3, and a subset of pre-T lymphoblastic lymphoma/leukemia (cortical T LBL/L).4,5
- Krenacs L, et al. Immunohistochemical detection of CD1A antigen in formalin-fixed and paraffin-embedded tissue sections with monoclonal antibody 010. J Pathol. 1993; 171:99-104.
- Angel CE, et al. Distinctive localization of antigen-presenting cells in human lymph nodes. Blood. 2009; 113:1257-67.
- Emile JF, et al. Langerhans' cell histiocytosis. Definitive diagnosis with the use of monoclonal antibody O10 on routinely paraffin-embedded samples. Am J Surg Pathol. 1995; 19:636-41.
- Stefano, AP et al. Acute leukemia immunophenotyping in bone-marrow routine sections. Br J Haematol. 1999; 105:394-401.
- Han X, et al. Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. Am J Clin Pathol. 2007; 127:528-44.
Specifications
- Reactivity: paraffin
- Control: Skin (Membranous); Thymus (Membranous)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC10131050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 101R-14 |
| 0.5 mL concentrate | 101R-15 |
| 1.0 mL concentrate | 101R-16 |
| 1.0 mL predilute ready-to-use | 101R-17 |
| 7.0 mL predilute ready-to-use | 101R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 101R-14 |
| 0.5 mL concentrate | 101R-15 |
| 1.0 mL concentrate | 101R-16 |
| 1.0 mL predilute ready-to-use | 101R-17 |
| 7.0 mL predilute ready-to-use | 101R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 101R-14 |
| 0.5 mL concentrate | 101R-15 |
| 1.0 mL concentrate | 101R-16 |
| 1.0 mL predilute ready-to-use | 101R-17 |
| 7.0 mL predilute ready-to-use | 101R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 101R-14-RUO |
| 0.5 mL concentrate (RUO) | 101R-15-RUO |
| 1.0 mL concentrate (RUO) | 101R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 101R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 101R-18-RUO |
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