Cathepsin K (3F9) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Cathepsin K is a papain-like cysteine protease that plays an important role in osteoclast function and has been identified as a target of the MiTF transcription factor family.1 Cathepsin K expression has been observed in translocation renal cell carcinoma (RCC), while other subtypes of RCC such as clear cell RCC do not react.2 Anti-Cathepsin K has been reported as a useful marker for several of the MiTF family of tumors including translocation RCC, melanoma and alveolar soft part sarcoma.3
- Motyckova G, et al. Linking osteopetrosis and pycnodysostosis: Regulation of cathepsin K expression by the microphthalmia transcription factor family. Proc Natl Acad Sci USA. 2001; 98:5798-803.
- Martignoni G, et al. Cathepsin-K immunoreactivity distinguishes MiTF/TFE family renal translocation carcinomas from other renal carcinomas. Mod Pathol. 2009; 22:1016-22.
- Rao Q, et al. Cathepsin K in the immunohistochemical diagnosis of melanocytic lesions. Int J Clin Exp Pathol. 2014; 7:1132-9.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: Xp11.2 translocation RCC
- Dilution Range: 1:25-1:100*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC40221040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 402M-14 |
| 0.5 mL concentrate | 402M-15 |
| 1 mL concentrate | 402M-16 |
| 1 mL predilute | 402M-17 |
| 7 mL predilute | 402M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 402M-14 |
| 0.5 mL concentrate | 402M-15 |
| 1 mL concentrate | 402M-16 |
| 1 mL predilute | 402M-17 |
| 7 mL predilute | 402M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 402M-14 |
| 0.5 mL concentrate | 402M-15 |
| 1 mL concentrate | 402M-16 |
| 1 mL predilute | 402M-17 |
| 7 mL predilute | 402M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 402M-14-RUO |
| 0.5 mL concentrate | 402M-15-RUO |
| 1 mL concentrate | 402M-16-RUO |
| 1 mL predilute | 402M-17-RUO |
| 7 mL predilute | 402M-18-RUO |
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