EZH2 (11) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2).1 It generates a methylation epigenetic mark at lysine 27 residue of histone H3 (H3K27me3) in order to silence gene expression.1 EZH2 target genes are involved in a variety of biological processes such as stem cell pluripotency, cell proliferation, and oncogenic transformation.1,2 Anti-EZH2 expression has been found in a variety of malignancies including prostate, breast, uterine, gastric, and renal cell cancers in addition to melanoma.1-4 Anti-EZH2 expression has been reported in non-small cell lung cancers and lymphoma.1 The EZH2 protein is usually not detected in normal breast ductal epithelium. EZH2 is usually expressed in follicular centers, but not in mantle zones, follicular and interfollicular T cells, plasma cells or NK/T cells. However, its expression can be seen in most B-cell and T-cell lymphomas.
- Ciarapica R, et al. Enhancer of zeste homolog 2 (EZH2) in pediatric soft tissue sarcomas: first implications. BMC Med. 2011; 9:63.
- Kader L, et al. In aggressive variants of non-Hodgkin lymphomas, Ezh2 is strongly expressed and polycomb repressive complex PRC1.4 dominates over PRC1.2. Virchows Arch. 2013; 463:697-711.
- Varambally S, et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature. 2002; 419:624-9.
- Tan J, et al. EZH2: biology, disease, and structure-based drug discovery. Acta Pharmacol. Sin. 2014; 35:161-74.
Specifications
- Reactivity: paraffin
- Visualization: nuclear
- Control: prostate adenocarcinoma, tonsil, breast carcinoma
- Dilution Range: 1:25-1:100*
Package Inserts
IFU
- IVD Rev. 2.0 (CMC41521020)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 415M-14 |
| 0.5 mL concentrate | 415M-15 |
| 1 mL concentrate | 415M-16 |
| 1 mL predilute | 415M-17 |
| 7 mL predilute | 415M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 415M-14 |
| 0.5 mL concentrate | 415M-15 |
| 1 mL concentrate | 415M-16 |
| 1 mL predilute | 415M-17 |
| 7 mL predilute | 415M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 415M-14 |
| 0.5 mL concentrate | 415M-15 |
| 1 mL concentrate | 415M-16 |
| 1 mL predilute | 415M-17 |
| 7 mL predilute | 415M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 415M-14-RUO |
| 0.5 mL concentrate | 415M-15-RUO |
| 1 mL concentrate | 415M-16-RUO |
| 1 mL predilute | 415M-17-RUO |
| 7 mL predilute | 415M-18-RUO |
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