Desmin (EP15) Rabbit Monoclonal Antibody
Specialties: Soft Tissue Pathology
Anti-desmin detects a protein that is expressed by cells of normal smooth, skeletal, and cardiac muscles. It has been suggested that desmin is primarily located at or near the periphery of Z lines in striated muscle fibrils. In smooth muscle, desmin interconnects cytoplasmic dense bodies with membrane bound dense plaques. Anti-desmin reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin. This antibody is used to demonstrate the myogenic components/derivation of tumors.1,2 Desmin can also be present in myofibroblasts and be focally positive in desmoid fibromatosis.3
- Altmannsberger M, et al. Am J Pathol 1985; 118:85-95.
- Debus E, et al. EMBO J. 1983; 2:2305-2312.
- Yamaguchi U, et al. Virchows Arch. 2004; 2:142-50.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic
- Control: skeletal muscle
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 1.0 (CMC24331010)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 243R-14 |
| 0.5 mL concentrate | 243R-15 |
| 1 mL concentrate | 243R-16 |
| 1 mL predilute | 243R-17 |
| 7 mL predilute | 243R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 243R-14 |
| 0.5 mL concentrate | 243R-15 |
| 1 mL concentrate | 243R-16 |
| 1 mL predilute | 243R-17 |
| 7 mL predilute | 243R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 243R-14 |
| 0.5 mL concentrate | 243R-15 |
| 1 mL concentrate | 243R-16 |
| 1 mL predilute | 243R-17 |
| 7 mL predilute | 243R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 243R-14-RUO |
| 0.5 mL concentrate | 243R-15-RUO |
| 1 mL concentrate | 243R-16-RUO |
| 1 mL predilute | 243R-17-RUO |
| 7 mL predilute | 243R-18-RUO |
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