Actin, Muscle Specific (HHF35) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology Soft Tissue Pathology
Muscle Specific Actin is a part of the actin family of proteins which are highly conserved, major components of the cytoskeleton. Anti-Muscle Specific Actin immunohistochemical reactivity is seen in skeletal, cardiac, and smooth muscle cells and can be seen in neoplasms with muscle differentiation such as leiomyomas and rhabdomyosarcomas. In contrast, anti-Muscle Specific Actin reactivity is typically not seen in endothelial cells, connective tissues, carcinomas, melanomas, lymphomas and most nonmyogenic sarcomas.1-5
- Gown AM, et al. Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions. Am J Pathol. 1986; 125:191.
- Schmidt RA, et al. Diagnosis of rhabdomyosarcomas with HHF35, a monoclonal antibody directed against muscle actins. Am J Pathol. 1988; 131:19-28.
- Azumi N, et al. Immunophenotypic diagnosis of leiomyosarcomas and rhabdomyosarcomas with monoclonal antibodies to muscle-specific actin and desmin in formalin-fixed tissue. Mod Pathol. 1988; 1:469-74.
- Rangdaeng S, et al. Comparative immunohistochemical staining for desmin and muscle-specific actin. A study of 576 cases. Am J Clin Pathol. 1991; 96:32-45.
- Tsukada T, et al. HHF35, a muscle actin-specific monoclonal antibody. II. Reactivity in normal, reactive, and neoplastic human tissues. Am J Pathol. 1987; 127:389-402.
Specifications
- Reactivity: paraffin
- Control: Skeletal Muscle (Cytoplasmic)
- Dilution Range: 1:10-1:50 *
Package Inserts
IFU
- IVD Rev. 5.0 (CMC20129050)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 201M-90 |
| 0.1 mL concentrate | 201M-94 |
| 0.5 mL concentrate | 201M-95 |
| 1.0 mL concentrate | 201M-96 |
| 1.0 mL predilute ready-to-use | 201M-97 |
| 7.0 mL predilute ready-to-use | 201M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 201M-90 |
| 0.1 mL concentrate | 201M-94 |
| 0.5 mL concentrate | 201M-95 |
| 1.0 mL concentrate | 201M-96 |
| 1.0 mL predilute ready-to-use | 201M-97 |
| 7.0 mL predilute ready-to-use | 201M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 201M-90 |
| 0.1 mL concentrate | 201M-94 |
| 0.5 mL concentrate | 201M-95 |
| 1.0 mL concentrate | 201M-96 |
| 1.0 mL predilute ready-to-use | 201M-97 |
| 7.0 mL predilute ready-to-use | 201M-98 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 201M-90-RUO |
| 0.1 mL concentrate (RUO) | 201M-94-RUO |
| 0.5 mL concentrate (RUO) | 201M-95-RUO |
| 1.0 mL concentrate (RUO) | 201M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 201M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 201M-98-RUO |
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