LEF1 (EP310) Rabbit Monoclonal Antibody
Specialties: Hematopathology
Lymphoid Enhancing Factor 1 (LEF1) is a transcription factor that belongs to the TCF/LEF family.1 LEF1 participates as a regulator in Wnt signaling pathways. LEF1 is an important factor in lymphopoiesis and is expressed normally in T and pro-B cells but not expressed in mature B cells.2 Strong nuclear expression of LEF1 has been observed in majority of chronic lymphocytic leukemia/small lymphocytic lymphoma cases and LEF1 is not detected in other small B cell lymphomas.2,3 Anti-LEF1 may be used as an aid for differentiation of chronic lymphocytic leukemia/small lymphocytic lymphoma from other small B cell lymphomas.2,3
- Granic K, et al. Developmental Biology. 2006; 295:219-31.
- Tando B, et al. Modern Pathology. 2011; 24:1433-43.
- Gandhirajan RK, et al. Neoplasia. 2010; 12:326-35.
Specifications
- Reactivity: paraffin
- Visualization: nuclear
- Control: tonsil, small lymphocytic lymphoma
- Dilution Range: 1:25-1:100*
Package Inserts
IFU
- IVD Rev. 1.0 (CMC44231010)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 442R-14 |
| 0.5 mL concentrate | 442R-15 |
| 1 mL concentrate | 442R-16 |
| 1 mL predilute | 442R-17 |
| 7 mL predilute | 442R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 442R-14 |
| 0.5 mL concentrate | 442R-15 |
| 1 mL concentrate | 442R-16 |
| 1 mL predilute | 442R-17 |
| 7 mL predilute | 442R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 442R-14 |
| 0.5 mL concentrate | 442R-15 |
| 1 mL concentrate | 442R-16 |
| 1 mL predilute | 442R-17 |
| 7 mL predilute | 442R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 442R-14-RUO |
| 0.5 mL concentrate | 442R-15-RUO |
| 1 mL concentrate | 442R-16-RUO |
| 1 mL predilute | 442R-17-RUO |
| 7 mL predilute | 442R-18-RUO |
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