NKX2.2 (EP336) Rabbit Monoclonal Antibody
Specialties: Anatomic Pathology Pediatric Pathology
NKX2.2 is a homeodomain transcription factor that plays a role in neuroendocrine and glial differentiation.1 NKX2.2 is upregulated in Ewing’s sarcoma as a result of the oncogenic EWS-FLI1 fusion protein.2,3 As one of many small round blue cell tumors, Ewing’s sarcoma can be difficult to diagnose due to the characteristic undifferentiated morphology.4 NKX2.2 has proven its utility as a sensitive maker for distinguishing Ewing’s sarcoma from other round blue cell tumors when used in a panel.1,5
- Yoshida A, et al. Am J Surg Pathol. 2012; 36:993-9.
- Yamamoto Y, et al. J Cytol. 2015; 32:30-32.
- Smith R, et al. Cancer Cell. 2006; 9:405-16.
- Rajwanshi A, et al. J Cytol. 2009; 26:1-10.
- Hung Y, et al. Mod Pathol. 2016; 29:370-80.
Specifications
- Reactivity: paraffin
- Visualization: nuclear
- Control: Ewing’s sarcoma, pancreas
- Dilution Range: 1:100-1:500*
Package Inserts
IFU
- IVD Rev. 1.0 (CMC44531010)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 445R-14 |
| 0.5 mL concentrate | 445R-15 |
| 1 mL concentrate | 445R-16 |
| 1 mL predilute | 445R-17 |
| 7 mL predilute | 445R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 445R-14 |
| 0.5 mL concentrate | 445R-15 |
| 1 mL concentrate | 445R-16 |
| 1 mL predilute | 445R-17 |
| 7 mL predilute | 445R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 445R-14 |
| 0.5 mL concentrate | 445R-15 |
| 1 mL concentrate | 445R-16 |
| 1 mL predilute | 445R-17 |
| 7 mL predilute | 445R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 445R-14-RUO |
| 0.5 mL concentrate | 445R-15-RUO |
| 1 mL concentrate | 445R-16-RUO |
| 1 mL predilute | 445R-17-RUO |
| 7 mL predilute | 445R-18-RUO |
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