CD15 (MMA) on lymph node, classic Hodgkin lymphoma.
CD15 (MMA) Mouse Monoclonal Antibody
Specialties: Hematopathology
Updated: 2017-05-24 08:46:09
CD15 is a carbohydrate antigen with the common trisaccharide structure 3-fucosyl-N-acetyl-lactosamine, also known as Lewis x (Lex) or stage-specific embryonic antigen 1 (SSEA-1).1-3 CD15 is expressed in myeloid cells and mediates neutrophil adhesion to dendritic cells.2-3 CD15 is also expressed in Reed-Sternberg cells and is thus a useful marker for identifying Hodgkin’s lymphoma.1
- Pellegrini W, et al. MMA monoclonal antibody is a superior anti-CD15 reagent for the diagnosis of classical Hodgkin's lymphoma. Haematologica. 2007; 92:708-9.
- Stocks SC, et al. Expression of the CD15 differentiation antigen (3-fucosyl-N-acetyl-lactosamine, LeX) on putative neutrophil adhesion molecules CR3 and NCA-160. Biochem J. 1990; 268: 275–80.
- Gadhoum SZ, et al. CD15 expression in human myeloid cell differentiation is regulated by sialidase activity. Nat Chem Biol. 2008; 4:751-7.
Specifications
- Reactivity: paraffin
- Visualization: cytoplasmic, membranous
- Control: Hodgkin's lymphoma
- Dilution Range: 1:25-1:100*
Package Inserts
IFU
- IVD Rev. 4.0 (CMC11521040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 115M-14 |
| 0.5 mL concentrate | 115M-15 |
| 1 mL concentrate | 115M-16 |
| 1 mL predilute | 115M-17 |
| 7 mL predilute | 115M-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 115M-14 |
| 0.5 mL concentrate | 115M-15 |
| 1 mL concentrate | 115M-16 |
| 1 mL predilute | 115M-17 |
| 7 mL predilute | 115M-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 115M-14 |
| 0.5 mL concentrate | 115M-15 |
| 1 mL concentrate | 115M-16 |
| 1 mL predilute | 115M-17 |
| 7 mL predilute | 115M-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate | 115M-14-RUO |
| 0.5 mL concentrate | 115M-15-RUO |
| 1 mL concentrate | 115M-16-RUO |
| 1 mL predilute | 115M-17-RUO |
| 7 mL predilute | 115M-18-RUO |
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