OCT-2 (EP284) Rabbit Monoclonal Antibody
Octamer transcription factor-2 (OCT-2) possesses a leucine zipper domain and belongs to the POU family of transcription factors. It specifically binds to the octamer motif (5-ATTTCAT-3), activates immunoglobulin gene expression and regulates transcription in a number of tissues. OCT-2 is important for the expression of B-cell specific genes, such as CD20 and CRISP-3. OCT-2 is expressed in mature B cells, predominantly germinal center B cells. Low expression of OCT-2 has been found in immature B cells, T cells and myelomonocytic cells. OCT-2 reactivity in epithelial cells and neuronal cells has also been reported. The OCT-2 antibody labels various B-cell lymphomas with strong expression in germinal center-derived lymphomas. In a study on Hodgkin's lymphoma (HL), OCT-2 positivity has been observed in 15 out of 15 lymphocyte predominance HLs, but none of the 29 classic HLs.
Specifications
- Reactivity: paraffin
- Visualization: nuclear
- Control: tonsil, non Hodgkin's lymphomas
- Dilution Range: 1:20*
Package Inserts
IFU:
IFU included with product
SDS:
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 1 mL concentrate | AC-0274 |
| 0.1 mL concentrate | AC-0274A |
This product is not available in Canada
For in vitro diagnostic (IVD) use in Europe
| 1 mL concentrate | AC-0274 |
| 0.1 mL concentrate | AC-0274A |
For research use only (RUO) in Japan
| 1 mL concentrate | AC-0274 |
| 0.1 mL concentrate | AC-0274A |
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