Burkitt lymphoma is positive for c-Myc.
c-Myc (EP121) Rabbit Monoclonal Primary Antibody
Specialties: Hematopathology
Updated: 2022-09-15 14:22:13
c-Myc is a transcription factor that drives the growth and proliferation of cells. c-Myc is amplified in many different solid and hematopoeitic tumors.1-5 Immunohistochemistry for c-Myc protein is used to identify the presence of a c-Myc translocation in various tumors, most frequently to aid in the diagnosis of Burkitt lymphoma.5
- Dang, C V. "c-Myc target genes involved in cell growth, apoptosis, and metabolism." Molecular and cellular biology vol. 19,1 (1999): 1-11.
- Toon, Christopher W et al. "Immunohistochemistry for myc predicts survival in colorectal cancer." PloS one vol. 9,2 e87456. 4 Feb. 2014
- Naidu, Rakesh et al. "Protein expression and molecular analysis of c-myc gene in primary breast carcinomas using immunohistochemistry and differential polymerase chain reaction." International journal of molecular medicine vol. 9,2 (2002): 189-96.
- Yang, Guang et al. "Combined c-Myc and caveolin-1 expression in human prostate carcinoma predicts prostate carcinoma progression." Cancer vol. 103,6 (2005): 1186-94.
- Bellan, Cristiana et al. "Burkitt lymphoma versus diffuse large B-cell lymphoma: a practical approach." Hematological oncology vol. 27,4 (2009): 182-5.
Specifications
- Reactivity: paraffin
- Control: Burkitt Lymphoma (Nuclear); Prostate Carcinoma (Nuclear)
- Dilution Range: 1:25-1:100 *
Package Inserts
IFU
- IVD Rev. 4.0 (CMC39531040)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 395R-14 |
| 0.5 mL concentrate | 395R-15 |
| 1.0 mL concentrate | 395R-16 |
| 1.0 mL predilute ready-to-use | 395R-17 |
| 7.0 mL predilute ready-to-use | 395R-18 |
For in vitro diagnostic (IVD) use in Canada
| 0.1 mL concentrate | 395R-14 |
| 0.5 mL concentrate | 395R-15 |
| 1.0 mL concentrate | 395R-16 |
| 1.0 mL predilute ready-to-use | 395R-17 |
| 7.0 mL predilute ready-to-use | 395R-18 |
For in vitro diagnostic (IVD) use in Europe
| 0.1 mL concentrate | 395R-14 |
| 0.5 mL concentrate | 395R-15 |
| 1.0 mL concentrate | 395R-16 |
| 1.0 mL predilute ready-to-use | 395R-17 |
| 7.0 mL predilute ready-to-use | 395R-18 |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 395R-14-RUO |
| 0.5 mL concentrate (RUO) | 395R-15-RUO |
| 1.0 mL concentrate (RUO) | 395R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 395R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 395R-18-RUO |
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