H3.3 G34W (RM263) Rabbit Monoclonal Antibody
Specialties: Soft Tissue Pathology
Detection of H3.3 G34W protein by immunohistochemistry with H3.3 G34W (RM263) Rabbit Monoclonal Antibody may be used to aid in the diagnosis of giant cell tumors of bone.
Histone proteins provide structural support for chromosomal DNA and regulate the accessibility of genes for transcription.1 Giant cell tumors of bone are locally aggressive primary bone tumors that usually occurs in the epiphysis of long bones in young adults. Giant cell tumors of bone harbor a histone protein mutation (H3.3 G34W) and show expression of the H3.3 G34W protein.1-4 Immunohistochemistry for H3.3 G34W shows a nuclear pattern of staining.
- Behjati, Sam et al. "Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone." Nature genetics vol. 45,12 (2013): 1479-82.
- Schaefer, Inga-Marie et al. "Immunohistochemistry for histone H3G34W and H3K36M is highly specific for giant cell tumor of bone and chondroblastoma, respectively, in FNA and core needle biopsy." Cancer cytopathology vol. 126,8 (2018): 552-566.
- Amary, Fernanda et al. "H3F3A (Histone 3.3) G34W Immunohistochemistry: A Reliable Marker Defining Benign and Malignant Giant Cell Tumor of Bone." The American journal of surgical pathology vol. 41,8 (2017): 1059-1068.
- Pasricha, Sunil et al. "Reliability and Role of Mutation-specific H3F3A (Histone 3-3) G34W Immunohistochemistry to Differentiate Giant Cell Tumor of Bone From its Clinicoradiologic and Histologic Mimics: An Institutional Study." Applied immunohistochemistry & molecular morphology : AIMM vol. 30,1 (2022): 36-41.
Specifications
- Reactivity: paraffin
- Control: Giant cell tumor of bone (Nuclear)
- Dilution Range: 1:100-1:200 *
Package Inserts
IFU
- IVD Rev. 0.0 (CMC49331000)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 493R-14 |
| 0.5 mL concentrate | 493R-15 |
| 1.0 mL concentrate | 493R-16 |
| 1.0 mL predilute ready-to-use | 493R-17 |
| 7.0 mL predilute ready-to-use | 493R-18 |
For research use only (RUO) in Canada
| 0.1 mL concentrate (RUO) | 493R-14-RUO |
| 1.0 mL concentrate (RUO) | 493R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 493R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 493R-18-RUO |
For research use only (RUO) in the EU
| 0.1 mL concentrate (RUO) | 493R-14-RUO |
| 1.0 mL concentrate (RUO) | 493R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 493R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 493R-18-RUO |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 493R-14-RUO |
| 1.0 mL concentrate (RUO) | 493R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 493R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 493R-18-RUO |
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