H3 K36M (RM193) Rabbit Monoclonal Antibody
Specialties: Soft Tissue Pathology
Detection of the H3 K36M protein by immunohistochemistry with H3 K36M (RM193) Rabbit Monoclonal Antibody may be used to aid in the diagnosis of chondroblastomas.
Histone proteins provide structural support for chromosomal DNA and regulate the accessibility of genes for transcription.1 H3 K36M is a mutant histone protein that is produced by a point mutation (K36M) in the H3.3 histone gene.1 Chondroblastomas, benign cartilaginous bone tumors, harbor H3 K36M mutations and show expression of the H3 K36M protein, which is not expressed in normal tissues.1-6 Immunohistochemistry for H3 K36M shows a nuclear pattern of staining.
- Anderson WJ, et al. Diagnostic Immunohistochemistry of Soft Tissue and Bone Tumors: An Update on Biomarkers That Correlate with Molecular Alterations. Diagnostics. 2021;11(4):690.
- Behjati S, et al. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. Nat Genet. 2013;45(12):1479-1482.
- Cleven AHG, et al. Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma. Am J Surg Pathol. 2015;39(11):1576-1583.
- Fang D, et al. The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science 2016;352(6291):1344-8.
- Amary MF, et al. The H3F3 K36M mutant antibody is a sensitive and specific marker for the diagnosis of chondroblastoma. Histopathology 2016;69(1):121-7.
- Lu C, et al. Histone H3K36M mutation and trimethylation patterns in chondroblastoma. Histopathology 2019;74(2):291-299.
Specifications
- Reactivity: paraffin
- Control: Chondroblastoma (Nuclear)
- Dilution Range: 1:100-1:200 *
Package Inserts
IFU
- IVD Rev. 0.0 (CMC49531000)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 0.1 mL concentrate | 495R-14 |
| 0.5 mL concentrate | 495R-15 |
| 1.0 mL concentrate | 495R-16 |
| 1.0 mL predilute ready-to-use | 495R-17 |
| 7.0 mL predilute ready-to-use | 495R-18 |
For research use only (RUO) in Canada
| 0.1 mL concentrate (RUO) | 495R-14-RUO |
| 1.0 mL concentrate (RUO) | 495R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 495R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 495R-18-RUO |
For research use only (RUO) in the EU
| 0.1 mL concentrate (RUO) | 495R-14-RUO |
| 1.0 mL concentrate (RUO) | 495R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 495R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 495R-18-RUO |
For research use only (RUO) in Japan
| 0.1 mL concentrate (RUO) | 495R-14-RUO |
| 1.0 mL concentrate (RUO) | 495R-16-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 495R-17-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 495R-18-RUO |
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