WT1 (6F-H2) Mouse Monoclonal Antibody
Specialties: Anatomic Pathology
Wilms’ tumor 1 protein (WT1) is a zinc finger transcription factor, normally expressed in tissues of mesodermal origin.1 The Wilms’ tumor gene encodes a protein that functions as a tumor suppressor gene mapped to human chromosome 11p13.2 Nuclear WT1 immunoreactivity has been observed in high frequencies in several types of mesoderm-derived tumors including epithelioid mesothelioma and ovarian serous carcinoma, and thus is used as a marker for these neoplasms.2,3,6
- May RJ, et al. Peptide epitopes from the Wilms' tumor 1 oncoprotein stimulate CD4+ and CD8+ T cells that recognize and kill human malignant mesothelioma tumor cells. Clin Cancer Res. 2007; 13: 4547-55.
- Ghanem MA, et al. Expression and prognostic value of Wilms' tumor 1 and early growth response 1 proteins in nephroblastoma. Clin Cancer Res 2000; 6(11):4265-71.
- Al-Hussaini M, et al. WT-1 assists in distinguishing ovarian from uterine serous carcinoma and in distinguishing between serous and endometrioid ovarian carcinoma. Histopathology 2004; 44(2):109-15.
- Maki T, et al. Differential detection of cytoplasmic Wilms tumor 1 expression by immunohistochemistry, western blotting and mRNA quantification. Int J Oncol 2017; 50(1):129-140.
- Galfione SK, et al. Diagnostic utility of WT-1 cytoplasmic stain in variety of vascular lesions. Int J Clin Exp Pathol 2014; 7(5):2536-43.
- Köbel M, et al. An immunohistochemical algorithm for ovarian carcinoma typing. Int J Gynecol Pathol 2016; 35(5):430-41
Specifications
- Reactivity: paraffin
- Control: Ovarian serous carcinoma (Nuclear); Mesothelioma (Nuclear); Kidney (Nuclear); Testis (Nuclear)
- Dilution Range: 1:100-1:500 *
Package Inserts
IFU
- IVD Rev. 8.0 (CMC34829080)
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Ordering Information
For in vitro diagnostic (IVD) use in USA
| 25.0 mL predilute ready-to-use | 348M-90 |
| 0.1 mL concentrate | 348M-94 |
| 0.5 mL concentrate | 348M-95 |
| 1.0 mL concentrate | 348M-96 |
| 1.0 mL predilute ready-to-use | 348M-97 |
| 7.0 mL predilute ready-to-use | 348M-98 |
For in vitro diagnostic (IVD) use in Canada
| 25.0 mL predilute ready-to-use | 348M-90 |
| 0.1 mL concentrate | 348M-94 |
| 0.5 mL concentrate | 348M-95 |
| 1.0 mL concentrate | 348M-96 |
| 1.0 mL predilute ready-to-use | 348M-97 |
| 7.0 mL predilute ready-to-use | 348M-98 |
For in vitro diagnostic (IVD) use in Europe
| 25.0 mL predilute ready-to-use | 348M-90 |
| 0.1 mL concentrate | 348M-94 |
| 0.5 mL concentrate | 348M-95 |
| 1.0 mL concentrate | 348M-96 |
| 1.0 mL predilute ready-to-use | 348M-97 |
| 7.0 mL predilute ready-to-use | 348M-98 |
For research use only (RUO) in Japan
| 25.0 mL predilute ready-to-use (RUO) | 348M-90-RUO |
| 0.1 mL concentrate (RUO) | 348M-94-RUO |
| 0.5 mL concentrate (RUO) | 348M-95-RUO |
| 1.0 mL concentrate (RUO) | 348M-96-RUO |
| 1.0 mL predilute ready-to-use (RUO) | 348M-97-RUO |
| 7.0 mL predilute ready-to-use (RUO) | 348M-98-RUO |
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